| NCT#: | NCT06876714 |
| NCT QR Code |  |
| Title: | ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab |
| Protocol: | A012303 |
| Cancer Type | Breast |
| Study Sponsor: | Alliance/NCI |
| Brief Summary: | This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body’s immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumab. |
| Study Type: | Interventional |
| Date Opened at SVH: | August 13, 2026 |
| Recruitment Status: | Recruiting |
| Study Population: | |
| Eligibility Criteria: | See SCHEMA |
| Principal Investigator: | Geetha N. Varma, MD, Oncology, Salinas Valley Health Cancer Care, (831) 755-1701 |
| Participating Institution: | Salinas Valley Health |
| Salinas Valley Health Clinical Research Program: | Terri Nielsen, MSJ, CCRP, Clinical Research Program |
| Link to ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT06876714?term=A012303&viewType=Card&rank=1&tab=study |
| Schema | Schema |
(Tumor Board) & Other Clinical Trials at Salinas Valley Health