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American Association for Cancer Research

  • GNAQ Induces Melanomagenesis in Mitfa-Independent Melanocyte Progenitors in a Zebrafish Model of Uveal Melanoma
    AbstractMelanocytes reside in diverse microenvironments that influence their susceptibility to oncogenic transformation; however, investigation of rare melanoma subsets has been limited by the lack of suitable preclinical animal models. In this study, we developed a primary, immunocompetent zebrafish model to study uveal melanoma using choroidal melanocyte–targeted injection and electroporation of plasmids encoding human GNAQQ209L together […]
  • SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma
    AbstractSETD2 is frequently mutated or deleted in clear cell renal cell carcinoma (ccRCC). Loss of SETD2 could create synthetic lethal dependencies that confer therapeutic vulnerabilities. In this study, we demonstrated that SETD2 deficiency promotes cytoplasmic mitochondrial DNA (mtDNA) leakage, leading to basal activation of cGAS-STING inflammatory signaling and increased apoptotic priming. This inflammatory state upregulated […]
  • Armored Chimeric Antigen Receptor T-cell Therapy Targets Antigen-Heterogeneous Glioma
    AbstractChimeric antigen receptor (CAR) T-cell therapy has shown early promise against glioblastoma, which lacks effective treatment options. However, two key challenges curtail efficacy: tumor-antigen heterogeneity and an immunosuppressive tumor microenvironment. CAR T cells engineered to secrete combinations of immunomodulatory proteins can reverse immune suppression and engage endogenous immunity. Through head-to-head in vivo comparisons of potentially […]
  • SIRT1 Inhibits T-cell Infiltration and Tertiary Lymphoid Structure Formation to Promote Radioimmunotherapy Resistance
    AbstractMicrosatellite stable (MSS) rectal cancer exhibits intrinsic resistance to immunotherapy. Although radiotherapy is frequently combined with immune checkpoint inhibitors (ICI) to augment immunotherapy responses, numerous immunologically cold tumors remain unresponsive. In this study, we observed a significant increase in electron transport chain activity, acetyl-CoA levels, and global lysine acetylation levels in patients achieving a pathologic […]
  • Signaling Under Stress: Targeting the Glucocorticoid Receptor in Cancer
    AbstractGlucocorticoid receptor (GR) signaling is critical to our physiology but is dysregulated in cancer by the pain, psychologic distress, iatrogenic morbidity, and pathology associated with an advanced, invasive disease. Many tumors exploit glucocorticoid signaling to provide antiapoptotic survival signals, stimulate growth and metastasis, suppress immune surveillance, and drive treatment resistance. Endogenous cortisol and exogenous glucocorticoids […]

Cancer.gov

  • NIH-funded study suggests that testosterone suppresses brain tumor growth in males
    In a new National Institutes of Health (NIH)-funded study, scientists at Cleveland Clinic discovered that hormones associated with male development may play a key role in limiting the growth of brain tumors in men. The research team found that the loss of androgen hormones, such as testosterone, in a preclinical model of glioblastoma drove tumor […]
  • NIH-funded AI model predicts cancer survival from single-cell tumor data
    In a National Institutes of Health (NIH)-funded study, researchers developed a cancer assessment tool that can identify high-risk patients and the tumor cells linked to that risk. The model, called scSurvival, uses a machine learning framework designed to analyze large-scale data at single-cell resolution.
  • Chronic inflammation leaves long-lasting impression on gut stem cells, increasing colorectal cancer risk
    In a new study, funded in part by the National Institutes of Health (NIH), researchers have uncovered a molecular mechanism that could explain how chronic gut inflammation may increase the risk of colorectal cancer. By simulating chronic colitis in mice and tracking the colon’s response during inflammation and recovery, scientists demonstrated that these changes increased […]
  • Researchers identify new blood markers that may detect early pancreatic cancer
    National Institutes of Health (NIH)-supported investigators have developed a blood test to find pancreatic ductal adenocarcinoma, one of the deadliest forms of cancer. The new test could improve survival rates from pancreatic cancer, which tends to be diagnosed at late stages when therapy is less likely to be effective. The findings were published in Clinical […]
  • NIH-led study reveals role of mobile DNA elements in lung cancer progression
    Using lung cancer biospecimens from the Sherlock-Lung study, an international team led by National Institutes of Health (NIH) researchers, identified key factors that drive tumor evolution and influence outcomes. Overall, the findings, published Dec. 10, 2025, in Nature, describe a previously unknown origin of some aggressive lung cancers.

JAMA Oncology – Current Issue

ClinicalTrials.gov – Cancer

STAT!Ref Evidence Alerts

ACCEL – Professional Insight, always within reach.

Professional Development Insights are part of the Salinas Valley Health’s Medical Staff Services and for our Physicians/APPs, we offer ACCEL.

ACCEL is a professional development platform created exclusively for Physicians and APPs at Salinas Valley Health. It offers expert-led content on the non-clinical aspects of medical practice — the things that shape daily work but rarely fit into formal training. Articles, Book Summaries, Videos, Audio/Visual… just for you!

  • Provided at no cost to Medical Staff members
  • Optional and self-directed
  • Private — not tracked or reported
  • Available on any computer or mobile device
  • Login and password provided by Medical Staff Services

Here are the Just In insights…

  • How to Think and Act Like a High Performer
    Dr. Ruth Gotian explains why success isn’t about copying routines—it’s about adopting the mindset behind them. Drawing on research with top performers, she shares the key principles that drive consistent excellence, including intrinsic motivation, perseverance, mastery, and continuous learning.
  • Future-Ready Leadership
    Future-ready leaders don't just react to change—they anticipate it. This learning path explores how to navigate uncertainty, embrace continuous learning, leverage emerging technologies, and lead with confidence in a rapidly evolving workplace. Discover practical strategies for staying relevant, building adaptability, and preparing yourself and your team for the future of work.
  • The Dynamics of Business Behavior
    Rather than looking outward, companies seeking transformation should instead understand and invest in their human contributors. In The Dynamics of Business Behavior, Beirem Ben Barrah and Philip Jordanov use behavioral science to improve organizational change management. Behavioral science contains a wealth of insights that companies can use to overcome organizational resistance to change, improve individual engagement, and sustain long-term growth. By embracing evidence-based interventions, developing a culture of psychological safety, and encouraging experimentation, you can transform your organization with the power of behavioral science.
  • Future Cultures
    Predicting the future is impossible, but you can shape the future with the right strategy. In Future Cultures, Scott Smith and Susan-Cox Smith describe how to improve culture, leadership, and organizational cohesion by adopting a future-oriented mindset. Internally and externally, change is a constant force affecting all organizations. Instead of panicking as the world, markets, and technologies change, you can prepare your organization for the future by developing a flexible, open-minded, and forward-thinking culture.
  • Inevitable
    The shift to electric vehicles (EVs) represents a massive transformation for the global automobile industry. The electric vehicle business offers great opportunities, but also significant risks. In Inevitable, journalist Mike Colias reviews the evolution of the electric vehicle sector and the implications for both small startup companies and large, established players.
  • Build Trust From the Inside Out
    The article focuses on the importance of personal trust as the foundation for effective leadership and strong relationships. It highlights that personal trust involves self-awareness, clarity of purpose, competence, continuous learning, motivation, and authentic communication, all of which enable individuals to build trust within themselves and extend it to others. The research by WiLD Leaders, a training and coaching firm, identifies key drivers of personal trust such as purpose, meaning, competence, drive, self-differentiation, investment in others, support networks, awareness, and readiness. Developing personal trust requires consistent self-reflection, embracing strengths and vulnerabilities, acting reliably, and seeking feedback, which collectively foster leadership […]
  • How to Leverage AI as Your Development Coach
    Julie Winkle Giulioni highlights how AI can support the development of essential soft skills like creativity, self-awareness, and leadership. By leveraging strategic prompts, AI becomes a valuable partner in personal and professional growth.
  • Dare to Disrupt
    In our fast-paced world, you’re either driving disruption or being driven by it. Many companies are close to disrupting their industry, but only those with the vision, persistence, and fearlessness to embrace innovation can successfully transform. In Dare to Disrupt, Brendan P. Keegan details the secrets of business growth and outlines eight pillars of organizational transformation. By cultivating a culture of innovation, leading with flexibility, and embracing failure, you can disrupt your industry with unparalleled growth.
  • Humans and AI
    Modern organizations are currently experiencing the Fourth Industrial Revolution, the Information Age. Technological developments occur faster than ever, making it vital to stay abreast of advances and trends that can shape and improve your organization’s performance. In Humans and AI, Jayne Mather outlines the organizational benefits of transitioning to an artificial intelligence (AI)-led, automation-first model while simultaneously cautioning the importance of maintaining people-centric values and approaches.
  • Read Your Mind
    In Read Your Mind, Oz Pearlman may not offer strategies to help you read minds, but he does the next best thing by teaching you how to read people. His simple-to-execute practices can work in a range of scenarios with minimal prep work. His book is a great read for anyone who wants to improve their ability to negotiate, persuade, lead, or connect with people in life or at work.
  • Balancing Usability and Ethics to Build Better Apps
    The article focuses on the ethical considerations and usability challenges in designing mobile apps and digital products. It highlights the importance of usability testing to ensure users can complete tasks efficiently, while also addressing concerns about apps that encourage impulsive or addictive behaviors through features like infinite scrolling and urgent notifications. Examples include the ethical design of the Libby digital library app versus the mixed impact of Microsoft Teams and the harmful effects linked to social media platforms such as TikTok and Instagram, as evidenced in the 2026 court case K.G.M. v. Meta et al. The article also discusses recent […]
  • Learning as a Routine
    The article focuses on improving organizational learning culture by embedding development into everyday work practices to balance immediate performance demands with future capability building. It highlights core tensions where task-focused environments prioritize efficiency over learning, leading to siloed expertise and missed opportunities for reflection and growth. To address this, it proposes cultivating learning agility through the 4Ps—purpose, process, playground, and proactiveness—which guide motivation, strategy, application, and initiative in learning. The article outlines five fundamental shifts, including integrating learning with work, fostering collective bench strength, promoting two-way feedback, and providing structured learning methods, supported by practical routines to embed these changes. […]
  • AI Strategy
    Lead artificial intelligence (AI) with clarity and confidence. In AI Strategy, world-renowned thought leader Bernard Marr explores a range of successful organizational AI implementation initiatives through crafting and executing a business-focused AI roadmap. Whether you’re just starting or scaling, you’ll learn to align AI adoption with strategy, identify use cases, manage data, and build scalable infrastructure while prioritizing ethics, talent, risk, and change management. Today, your organization must be an AI organization.
  • Building Influence at Work
    Influence plays a critical role in building relationships, driving collaboration, and advancing ideas at work. In this learning path, you’ll explore practical strategies for strengthening your ability to persuade others, communicate with greater impact, and influence outcomes—even when you don’t have formal authority.
  • Self-Talk Your Way into a Growth Mindset
    Cable explains how to replace negative inner chatter with positive self-talk, making challenges feel like opportunities for growth rather than obstacles to success.
  • I Respectfully Disagree
    In I Respectfully Disagree, CEO Justin Jones-Fosu introduces the Five Pillars of Bridging the Divide framework to help you seek the gray, build dialogue, and find common ground. By applying powerful tools, real-life scenarios, and practical strategies, readers of every personal and professional level will be able to positively approach disagreements, humanize the “other,” and recognize the value and worth of all individuals, even amid disagreements.
  • Essential
    In an increasingly polarized and digital world, leading with humanity has never been more important. In Essential, Christie Smith, PhD, and Kelly Monahan, PhD, outline an effective leadership style focused on relationship building, transparency, and human empathy. Advancements in artificial intelligence (AI) are causing organizations to invest heavily in technology, but they fail to invest in the people that determine their success. By shifting to a leadership style that encourages collaboration, welcomes diverse perspectives, and prioritizes well-being, you can create an innovative, productive, and empathic culture in your organization.
  • How to Improve Your Critical Thinking with AI
    Lisa Bodell explains why the real value of AI isn’t in the first answer—it’s in how you challenge it. By pushing back, questioning assumptions, and demanding proof, you can turn AI into a tool for sharper thinking, stronger insights, and better decisions.
  • Recharge
    In the workplace, mental health conversations carry a negative stigma. Stress is expected, resilience is rewarded, and personal challenges aren’t discussed. However, we can build a healthier, happier, and more productive culture by having real conversations about mental health. In Recharge, David Ko combines his personal experiences and interviews with mental health professionals to outline the modern mental health crisis and endorse the simple power of mental health conversations. By making a habit of checking your mental battery, strengthening your mind-body connection, and utilizing new technology to track your progress, you can begin every day recharged and ready to excel.
  • The Problem with Change
    To keep up with rapidly evolving industries, leaders are often urged to fail fast, disrupt everything, and pick up the pieces later. While innovation is necessary for growth, many companies risk destroying their value by committing to unwieldy change plans. In The Problem with Change, Ashley Goodall describes the downsides of constant disruption and advocates for the necessity of stability, predictability, and humanity as core organizational values. By prioritizing the needs of employees, reducing uncertainty, and cultivating belonging, you can lead your organization away from chaos toward positive change.

*For providers of Salinas Valley Health, if you need access to any particular article referred to in these news feeds, please email Library@SalinasValleyHealth.com