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American Association for Cancer Research

  • SEPTIN7 Enhances Tumorigenesis and Therapeutic Resistance in Hepatocellular Carcinoma by Promoting FGFR4 Stabilization and Recycling
    AbstractHepatocellular carcinoma (HCC) is a highly lethal malignancy with rapid onset of drug resistance and high recurrence rate, partly driven by cancer stem cells (CSC). In this study, we identified a small GTPases SEPTIN7 as a critical regulator of tumorigenesis and therapeutic resistance in HCC. SEPTIN7 was significantly upregulated in human HCC samples with high […]
  • Immune Checkpoint Blockade Augments Lymphodepleting Chemotherapy–Induced Antitumor Immunity by Expanding Effector CD8 + T-cell Clones
    AbstractCancer treatment using immune checkpoint blockade (ICB) with anti–programmed cell death protein 1 (αPD-1) and anti–cytotoxic T lymphocyte–associated protein 4 (αCTLA-4) has been successful. However, primary and acquired resistance limits clinical benefit. To improve the effectiveness of ICB therapies, strategies that reorchestrate antitumor immunity through mechanism-based drug combinations are being actively explored. The alkylating chemotherapeutic […]
  • Stromal–Immune Interactions Promote Immune Suppression in Intraperitoneal Metastasis of Ovarian Carcinoma
    AbstractHigh-grade serous (tubo-ovarian) carcinoma (HGSC) is the most lethal gynecologic malignancy and the most common form of ovarian cancer. Most patients (75%) are diagnosed at advanced disease stages, with widespread peritoneal dissemination leading to a poor prognosis. In this study, we characterized the interactions between fibroblasts and immune cells that facilitate the formation of a […]
  • A Barrier Betrayed: Hillock in Lung Squamous Cell Carcinoma
    Airway hillocks are specialized, stratified squamous epithelial structures featuring luminal barrier cells supported by a dedicated basal stem cell population. In this issue of Cancer Research, Izzo and colleagues identify a distinct population of slow-cycling KRT13+ hillock-like tumor cells in lung squamous cell carcinoma, a cell state conserved across multiple squamous cell carcinoma (SCC) models. […]
  • Lactylation Orchestrates Immune Evasion in Gastric Cancer through KDM5B-Mediated Histone Demethylation
    AbstractImmune evasion driven by the tumor microenvironment is a major obstacle to effective immunotherapy in gastric cancer. To overcome this barrier, a detailed understanding of the mechanisms by which gastric cancer circumvents antitumor immunity is essential. In this study, we identified KDM5B as a pivotal epigenetic–metabolic orchestrator of immune evasion in gastric cancer. Clinically, KDM5B […]

Cancer.gov

  • NIH-funded study suggests that testosterone suppresses brain tumor growth in males
    In a new National Institutes of Health (NIH)-funded study, scientists at Cleveland Clinic discovered that hormones associated with male development may play a key role in limiting the growth of brain tumors in men. The research team found that the loss of androgen hormones, such as testosterone, in a preclinical model of glioblastoma drove tumor […]
  • NIH-funded AI model predicts cancer survival from single-cell tumor data
    In a National Institutes of Health (NIH)-funded study, researchers developed a cancer assessment tool that can identify high-risk patients and the tumor cells linked to that risk. The model, called scSurvival, uses a machine learning framework designed to analyze large-scale data at single-cell resolution.
  • Chronic inflammation leaves long-lasting impression on gut stem cells, increasing colorectal cancer risk
    In a new study, funded in part by the National Institutes of Health (NIH), researchers have uncovered a molecular mechanism that could explain how chronic gut inflammation may increase the risk of colorectal cancer. By simulating chronic colitis in mice and tracking the colon’s response during inflammation and recovery, scientists demonstrated that these changes increased […]
  • Researchers identify new blood markers that may detect early pancreatic cancer
    National Institutes of Health (NIH)-supported investigators have developed a blood test to find pancreatic ductal adenocarcinoma, one of the deadliest forms of cancer. The new test could improve survival rates from pancreatic cancer, which tends to be diagnosed at late stages when therapy is less likely to be effective. The findings were published in Clinical […]
  • NIH-led study reveals role of mobile DNA elements in lung cancer progression
    Using lung cancer biospecimens from the Sherlock-Lung study, an international team led by National Institutes of Health (NIH) researchers, identified key factors that drive tumor evolution and influence outcomes. Overall, the findings, published Dec. 10, 2025, in Nature, describe a previously unknown origin of some aggressive lung cancers.

JAMA Oncology – Current Issue

ClinicalTrials.gov – Cancer

STAT!Ref Evidence Alerts

ACCEL – Professional Insight, always within reach.

Professional Development Insights are part of the Salinas Valley Health’s Medical Staff Services and for our Physicians/APPs, we offer ACCEL.

ACCEL is a professional development platform created exclusively for Physicians and APPs at Salinas Valley Health. It offers expert-led content on the non-clinical aspects of medical practice — the things that shape daily work but rarely fit into formal training. Articles, Book Summaries, Videos, Audio/Visual… just for you!

  • Provided at no cost to Medical Staff members
  • Optional and self-directed
  • Private — not tracked or reported
  • Available on any computer or mobile device
  • Login and password provided by Medical Staff Services

Here are the Just In insights…

  • The Future-Ready Brand
    by Mitch Duckler
    Book Summary · 15 min — Shifts in consumer demands and expectations, driven by emerging interactive technologies, are reshaping how brands position themselves. While these developments offer companies exciting growth opportunities, they also bear risks. In The Future-Ready Brand, Mitch Duckler guides you through possibilities and pitfalls of these rapidly unfolding changes. He balances big-picture perspectives with fine-grained insights, all with an eye to the technologies and consumer trends driving the future of branding and content marketing. It’s a book for leaders and marketers who want to increase their competitive advantage by future-proofing their brands.
  • The Power Pause
    by Neha Ruch
    Book Summary · 15 min — In The Power Pause, Neha Ruch describes the challenges new stay-at-home parents face and the immense opportunities available to them to build a meaningful and enriching life. While the book is geared toward working women making the shift to home life, the lessons can easily be applied to men who are considering a full-time family focus. This book is a must-read for any working professional who’s constructing a plan for parenthood and what life will look like before, during, and after their professional power pause.
  • The Accidental CIO
    by Scott Millett
    Book Summary · 15 min — A good CIO can make or break a company. However, this is a relatively new role that’s not largely understood. In The Accidental CIO, Scott Millett shares valuable insights from his more than 20 years of IT experience that can help you transition into an IT leadership role. By following Millett’s playbook, you can create and execute an effective IT strategy, design an operating model to deliver results, and create an IT organization that’s focused on generating enterprise value.
  • How to Practice Courageous Communication
    by Henna Pryor
    Video · 3 min 30 sec — Henna Pryor explores why speaking with honesty, clarity, and respect will define the next era of leadership. Learn how courageous communication helps teams build trust and move forward together.
  • People Problems
    by Nicole Otto,Lindsey Newt,Kat Schneider,Kerry Benjamin,Hilary Angrove,Job Van Der Voort
    Article · 5 min — The article focuses on insights from six business leaders regarding the challenges and lessons learned from difficult hiring and firing decisions. Key themes include the importance of timely action when recognizing the right or wrong fit, prioritizing team culture and flexibility over expertise in early-stage companies, and distinguishing loyalty from what benefits the organization and individuals. Leaders also emphasize the need to assess personnel decisions from a broad perspective, considering organizational goals, team dynamics, and individual contributions. These reflections highlight the complexity and significance of managing human resources in business growth.
  • The New CEO
    by Ty Wiggins
    Book Summary · 15 min — Achieving a CEO position is a major career accomplishment, but it presents a wide range of challenges for those who transition into the role for the first time. In The New CEO, Ty Wiggins, PhD, details the common mistakes made by first-time CEOs and outlines strategies to help you improve your early performance in the role. Switching from working with a team to overseeing an entire organization requires you to communicate clearly, stay connected with all business areas, and be accountable to competing stakeholders. By building a strong leadership team, learning when to accelerate […]
  • The Employee Experience Revolution
    by John R. Dijulius,David D. Murray
    Book Summary · 15 min — The lack of meaning along with widespread burnout in many organizations are holding back financial growth and employee well-being. As customer and employee experience plummets across industries, a new opportunity arises for purpose-driven leaders. In The Employee Experience Revolution, John R. DiJulius III and David D. Murray review the current state of employee well-being and outline the actions leaders can take to create a world-class culture that inspires and fulfills. By leading with transparency, communicating with clarity, and developing others with compassion, you can accelerate into the future with human-centric leadership.
  • Thinking Critically in the Age of AI
    Learning Path — AI can generate answers in seconds-but thinking critically about those answers still requires you. In this learning path, you’ll learn how to question assumptions, evaluate information from multiple perspectives, avoid jumping to conclusions, and think with greater focus and flexibility so you can make better decisions in the age of AI.
  • How I Got My 900 Employees to Love AI
    by Wes Schroll
    Article · 5 min — The article focuses on how the founder and CEO of Fetch, a rewards app company with 13 million monthly users and $700 million in gross revenue, temporarily shut down operations for nearly a week to encourage all 900 employees to experiment with artificial intelligence (AI) tools. This initiative, called AI Week, involved canceling meetings and client interactions to allow uninterrupted time for innovation, resulting in the creation of multiple AI-driven solutions, including a customer shopping agent and an internal data tool that accelerates market insights. The company experienced a significant productivity boost, with revenue per […]
  • Don't Be the Boss-Be the Leader
    by Thom Mayer
    Video · 3 min 30 sec — Being the boss and being a leader are not the same thing. Thom Mayer challenges conventional ideas about authority, explaining why great leaders focus on elevating others, building trust, and helping every member of the team feel valued especially in times of crisis.
  • B2B Content Marketing Strategy
    by Devin Bramhall
    Book Summary · 15 min — Nearly every business has a content marketing strategy, which can make it difficult to stand out and build community. However, the oversaturated nature of business-to-business (B2B) marketing presents a real advantage for an organization that’s willing to rethink its process. In B2B Content Marketing Strategy, Devin Bramhall unpacks the common mistakes content marketers make and advocates for a strategy centered around community growth, relationship building, and trust. By focusing on resonance over knowledge, exchange over extraction, and authenticity over branding, you can create a sustainable content marketing strategy that has real impact on your […]
  • Why Workplace Wellbeing Matters
    by Jan-Emmanuel De Neve,George Ward
    Book Summary · 15 min — Workplace wellbeing can be defined by how employees feel at work and about their work. Although many companies believe workplace wellness is important, they often don’t invest in it. In Why Workplace Wellbeing Matters, Jan-Emmanuel De Neve and George Ward offer actionable insights and a data-driven perspective to make a business case for workplace wellbeing.
  • Unleashing AI
    by Milan Frankl
    Book Summary · 15 min — Artificial intelligence (AI) is revolutionizing the way we communicate, work, and structure our organizations. In Unleashing AI, Dr. Milan Frankl breaks down the fundamentals of AI and provides strategies to help you integrate AI into your business. The business landscape is fast-paced and filled with data that we don’t have the time or resources to process. AI systems introduce forecasting, real-time assessment, and data-driven optimization to enable rapid data processing for core business functions. By aligning AI development with business goals, adhering to ethical standards, and investing in data management, you can unleash hidden […]
  • When Reorgs Go Wrong
    by Ryann K. Ellis
    Article · 5 min — This article examines the challenges companies face during organizational restructuring, highlighting a significant gap between leadership expectations and employee experiences. Research from Bain & Company reveals that while 88 percent of leaders believe reorganizations will meet goals, only 36 percent of employees agree, largely due to unclear decision rights, confusing interdependencies, and insufficient support. The article emphasizes the critical role of learning and development (L&D) in equipping middle managers with tools and coaching to help teams adapt to new workflows and behaviors. A case study of an energy company illustrates how focusing beyond structural changes—by […]
  • The Conscious Style Guide
    by Karen Yin
    Book Summary · 15 min — Instead of rigid rules, people need a framework for evaluating language so they can make skillful choices for their situation. Both a philosophy and a practice, conscious language promotes equity and freedom by encouraging critical thinking about context, going beyond words to address portrayals, framing, and representation. In The Conscious Style Guide, award-winning writer Karen Yin provides a reference book that empowers readers to create flexible, personalized systems for thinking about today’s constantly evolving language.
  • The Mentorship Edge
    by Deborah Heiser
    Book Summary · 15 min — In a chaotic and rapidly changing world, one of the oldest forms of knowledge transfer—mentorship—emerges as a powerful catalyst for personal growth, professional development, and relationship building. In The Mentorship Edge, Deborah Heiser, PhD, breaks down the core components of mentorship, explains the transformational power of lateral mentoring, and outlines strategies to implement mentorship initiatives in organizations. By following intrinsic motivations, reflecting on your unique gifts, and forming relationships rooted in reciprocation, you can leverage mentorship to grow, find purpose, and build community.
  • Job Crafting: How to Inspire Performance
    by Dan Cable
    Video · 3 min 30 sec — Job crafting empowers employees to personalize their work within defined outcomes. Dan Cable shares 3 ways to craft jobs in a way that enhances engagement, motivation, and performance.
  • I See You
    by Amy Kemp
    Book Summary · 15 min — You have the ability to increase your influence, impact, and income. In I See You, coach and CEO Amy Kemp takes you on a journey of self-recognition and women empowerment that begins with being honest about where you are and what you want. Through personal stories, best practices, and hands-on exercises, you’ll create space for growth, uncover what’s inside of you, and recognize the intuition, strength, and clarity you already possess.
  • How to Develop a Network of Support and Insight
    by Ruth Gotian
    Video · 3 min 30 sec — One mentor isn’t enough to support long-term growth. Ruth Gotian introduces the idea of building a “mentoring team” made up of diverse voices, perspectives, and experiences, showing how a more intentional network can broaden your thinking and open new paths for success.
  • Working Better Together
    Learning Path — The best results happen when people work together with purpose. In this learning path, you'll discover how to strengthen collaboration across teams, break down barriers, and build the connections that lead to better decisions and stronger results.

*For providers of Salinas Valley Health, if you need access to any particular article referred to in these news feeds, please email Library@SalinasValleyHealth.com